Ondansetron Plus Dexamethasone With or Without Metoclopramide as Antiemetic Prophylaxis After Receiving Cisplatin

• Status: Completed
• Trial end date: 2010-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to assess the efficacy and tolerability of metoclopramide added to standard antiemetic regimen for prophylaxis of cisplatin-induced emesis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahidol University
• Collaborator: Siriraj Hospital
• Treatments: Antiemetics; BB 1101; Cisplatin; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Metoclopramide; Ondansetron

Criteria

Inclusion Criteria:

• schedule to receive first cycle of cisplatin > 50 mg/m^2

• pathologically or histologically confirmed solid cancer

• more than 18 years old

• creatinine clearance more than 50 ml/min

• aminotransferase less than 2 times of upper normal limit

Exclusion Criteria:

• pregnant woman

• patients with episode of vomiting within 24 hours prior to chemotherapy session

• gut obstruction

• brain metastasis

• abdominal or pelvic irradiation

• no history of allergy to study drugs