Ondansetron vs Prochlorperazine for Nausea and Vomiting in the Emergency Department

• Status: Completed
• Trial end date: 2008-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will compare the effect of prochlorperazine and ondansetron for the treatment of nausea and vomiting in the emergency department.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Emory University
• Treatments: Ondansetron; Prochlorperazine

Criteria

Inclusion Criteria:

• Patients presenting to the ED with at least one of the following

• Nausea

• Vomiting documented in the ED

Exclusion Criteria:

• Previous treatment in the ED with Ondansetron, prochlorperazine, promethazine or metaclopramide

• Patients with missed last menstrual period

• Pregnancy

• Age < 18 years old

• Treatment with antineoplastic agents within 7 days prior to randomization

• Irritable bowel syndrome

• Gastroparesis

• Suspected gastrointestinal bleed

• Suspected intestinal obstruction

• Preexisting motor disorder (Restless-leg syndrome or Parkinson's disease)

• Traumatic brain injury upon admission to ED

• Intracranial hemorrhage upon admission to ED

• Patients unable to read, write or communicate in the English language

• Patients leaving the ED against medical advice