Overview

One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis

Status:
Unknown status

Trial end date:
2020-08-01

Target enrollment:
0

Participant gender:
All

Summary

The purpose of this study is to observe the serological response to 1 or 3 weekly doses of benzathine penicillin G in patients with early syphilis.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Jun Li

Treatments:

Penicillin G
Penicillin G Benzathine
Penicillin G Procaine
Penicillins

Criteria

Inclusion Criteria:

1. Persons with confirmed early symptomatic syphilis (primary or secondary) or high-titer
latent syphilis

2. A rapid plasma reagin (RPR) test was positive, with a titer were 1:4 or higher. In
addition, Treponema pallidum particle agglutination assay and/or fluorescent
treponemal antibody absorption test were reactive.

Exclusion Criteria:

1.Patients who were pregnancy, known allergy to penicillin, use of antibiotics active
against syphilis during the preceding six months for symptomatic cases or during the
preceding two years for asymptomatic cases, and concurrent illnesses requiring treatment
with antibiotics effective against syphilis. 2. if RPR titers were found to be 1:4 or less
or the T. pallidum particle agglutination test was nonreactive, participants were
retrospectively excluded from the trial unless primary syphilis was confirmed by the
finding of T. pallidum in ulcer exudates on direct immunofluorescence

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