One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators

• Status: Completed
• Trial end date: 2007-09-01
• Target enrollment: 0
• Participant gender: All

Summary

One-lung ventilation; organ protection; volatile anesthetics

One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study:

1. Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse?

2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium.

• Trial with immunomodulatory product / biological

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Zurich
• Treatments: Propofol; Sevoflurane

Criteria

Inclusion criteria:

• Thoracic surgery (thoracotomy, thoracoscopy) with one-lung ventilation

Exclusion criteria:

• Immunosuppressive therapy

• Ongoing inflammatory processes