Open Label Phase I Study To Evaluate the Safety of Combination Therapy With AZT and Interferon-Beta in Patients With AIDS Related Kaposi's Sarcoma

• Status: Completed
• Trial end date: 1991-07-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine the highest tolerated dose of the safety and tolerance of interferon beta (IFN-B) when it is given at the same time as zidovudine (AZT) to patients with early AIDS related Kaposi's sarcoma. In addition, the studies will determine preliminary data on response, immune function, and subcutaneous absorption.

IFN-B has demonstrated a dose-dependent ability to suppress the replication of HIV in the test tube. In addition, previous studies have shown AZT to be an effective inhibitor of HIV reverse transcriptase; Phase I and II study benefits of AZT treatment include increased objective clinical improvement, decreased mortality rate, and decreased incidence of opportunistic infections. Long-term AZT use, however, presents possible limitations secondary to intolerance. This study, therefore, will investigate the potential antiviral activities of a combination of IFN-B and AZT to determine the safety and efficacy of such treatment in patients with AIDS related Kaposi's sarcoma. It is believed that combination drug therapy consisting of low doses of each drug will reduce the potential of toxicity, treatment failures, and disease recurrences resulting from drug-resistant virus mutants.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
• Treatments: Interferon beta-1b; Interferon-beta; Interferons; Zidovudine

Criteria

Inclusion Criteria

Concurrent Treatment:

Allowed:

• Local radiotherapy or laser therapy to cosmetically apparent Kaposi's lesions, provided the dose to any one lesion does not exceed 3000 gray and the total surface area of all lesions treated does not exceed 10 cm2 during the course of the trial.

Patients must demonstrate the following clinical and laboratory findings:

• Positive for HIV by federally licensed ELISA test.

• Acceptable bone marrow function.

• Acceptable renal function.

• Acceptable hepatic function.

Exclusion Criteria

Concurrent Medication:

Excluded:

• Other potentially antiretroviral compounds.

Patients will be excluded from the study for the following reasons:

• Concurrent, active opportunistic infections requiring therapy.

• Extensive Kaposi's sarcoma with more than 100 cutaneous lesions, requiring systemic chemotherapy, prior treatment with more than one chemotherapy regimen, excluding intralesional therapy, or symptomatic visceral Kaposi's sarcoma.

• Evidence of clinically significant cardiac dysfunction (New York Heart Association grade III or IV).

• History of malignant neoplasms other than nonmelanomatous skin cancer or cancer in situ of the cervix.

• Proteinuria of 2+ or greater and/or 24-hour urine protein of greater than 1.

Prior Medication:

Excluded:

• More than one chemotherapy regimen for Kaposi's sarcoma.

• Any interferon preparation or zidovudine (AZT).

• Excluded within 30 days of study entry:

• Other immunomodifiers.

• Acyclovir.

• Other investigational drugs.

• Excluded within 60 days of study entry:

• Cytotoxic therapy.

Patients may not have any of the following diseases or symptoms:

• Development of an AIDS-defining opportunistic infection, other than oral thrush or localized zoster.

• Non-Kaposi's sarcoma, AIDS-defining malignancy.