Open-Label Pilot Study of Namenda in Adult Subjects With ADHD and ADHD NOS
Status:
Completed
Trial end date:
2009-10-01
Target enrollment:
Participant gender:
Summary
The primary objective of the study is to assess the efficacy and tolerability of a 12-week
trial of memantine hydrochloride administered twice daily in 20 adults (ages 18-55) with ADHD
and ADHD NOS. Improvement will be defined as: 1) changes from baseline on the
investigator-rated DSM-IV based ADHD Rating Scale; 2) changes from baseline in a
questionnaire aimed at assessing executive functions (BRIEF); and 3) changes from screening
in a computerized neuropsychological battery (CANTAB). We hypothesize that memantine
hydrochloride will be associated with improving ADHD symptoms and associated deficits in
executive functions. We also expect that memantine will be well-tolerated with predictable
adverse events.