Open-Label Single Arm Study to Evaluate Voxelotor for Improving Oxygen Saturation in Adults
Status:
Not yet recruiting
Trial end date:
2023-03-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to evaluate the efficacy of voxelotor for increasing oxygen
saturation in 20 patients with hypoxemia. Specifically, the SpO2/FiO2 ratio will be compared
before and after voxelotor use at rest and during exercise (ambulatory patients only). The
primary study objective is to evaluate the efficacy of voxelotor for increasing oxygen
saturation in patients with hypoxic hypoxemia as a result of end-stage lung disease or acute
lung injury. The secondary objective is to evaluate the efficacy of voxelotor on allowing
de-escalation of supplemental oxygen support.