Open Trial Determining Antidepressant Effects of Omega-3 Supplementation During Pregnancy

• Status: Terminated
• Trial end date: 2012-02-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine if omega-3 polyunsaturated fatty acids as a monotherapy have antidepressant effects during pregnancy. It will also provide pilot data pertaining to relationships between apparent response to omega-3 monotherapy and both plasma cytokine and erythrocyte essential fatty acid concentrations.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: William Coryell
• Treatments: Antidepressive Agents

Criteria

Inclusion Criteria:

1. Women with uncomplicated pregnancy within the 1st or 2nd trimester of pregnancy

2. Score of 10 or greater on the nine item Patient Health Questionnaire (PHQ-9) for depression

Exclusion Criteria:

1. antidepressant use in preceding month

2. use in previous 4 weeks of psychotropic medications other than hypnotics or benzodiazepines in diazepam dose-equivalents greater than or equal to 2mg/day for insomnia

3. Fish allergy

4. initiation of regularly scheduled course of psychotherapy within previous 2 months