The overall goal of this research project is to test a newly developed behavioral therapy to
enhance the efficacy of naltrexone maintenance and make it a viable alternative to methadone
maintenance or detoxification methods for treatment of opiate dependence. HYPOTHESES:
1. Outpatient treatment with Behavioral Naltrexone Therapy will yield a lower rate of
relapse to illicit opiates compared to naltrexone plus Compliance Enhancement (CE)
Therapy.
2. Lifetime history of depression will predict dysphoria and non-compliance with
naltrexone.