Opioid Agonist and Antagonist Effects on Opioid Dependence

• Status: Terminated
• Trial end date: 2006-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the acute agonist and antagonist effects of a full opioid agonist medication, an opioid antagonist medication, and a partial opioid agonist medication in individuals who have different levels of physical opioid dependence.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Collaborator: Johns Hopkins University
• Treatments: Analgesics, Opioid; Methadone; Narcotic Antagonists

Criteria

Inclusion Criteria:

• Active opioid dependence

• Qualifies for opioid agonist treatment (e.g., methadone or buprenorphine)

• Fulfills DSM-IV diagnostic criteria for opioid dependence

Exclusion Criteria:

• Significant medical problems, including insulin dependent diabetes mellitus

• Non-substance use psychiatric disorders (e.g., schizophrenia)

• Currently seeking treatment for substance abuse