Overview

Opioid Based Anaesthesia vs Opioid Free Anesthesia in Cleft Lip, Palate ,Alveolus Surgery.

Status:
Unknown status

Trial end date:
2020-10-04

Target enrollment:
0

Participant gender:
All

Summary

Peri-operative opioid administration has long been one of the three pillars of 'balanced anaesthesia',over the span of just a few years,opioids were widely used in perioperative analgesia because of pain as the fifth vital sign.However, opioid administration is not without concern and is associated with many side-effects such as constipation, urinary retention, respiratory depression and postoperative nausea and vomiting .Cleft lip,palate,alveolus are common craniofacial abnormalities and usually require surgical repair.These patients have risks for various perioperative complications due to their young age and craniofacial abnormalities. This study was designed to compare the effects of opioid based anesthesia（OBA） and opioid free anesthesia(OFA )on perioperative complications in patients with in cleft lip,palate,alveolus surgery, including respiratory depression, postoperative nausea and vomiting, hemodynamic effects, etc.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Treatments:

Analgesics, Opioid
Anesthetics
Dexmedetomidine
Fentanyl
Ketamine
Remifentanil
Sevoflurane

Criteria

Inclusion Criteria:

- American Society Anesthesia I, II；

- Age between 3 months and 12 years;

Exclusion Criteria:

- allergy to anesthetic and analgesic drugs;

- history of neuromuscular;

- renal, neurological, hepatic disease;

- cardiopulmonary diseases;

- bradycardia