Opioid Effects on Swallowing and Esophageal Sphincter Pressure

• Status: Completed
• Trial end date: 2010-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether a dopamine receptor antagonist metoclopramide can counteract opioid induced effects on esophageal motility and lower esophageal sphincter. The aim of this study is also to evaluate if the opioid antagonist naloxone reduces the opioid induced pharyngeal and esophageal dysfunction.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Region Örebro County
• Treatments: Metoclopramide; Naloxone; Remifentanil

Criteria

Inclusion Criteria:

1. 18 - 40 year old healthy volunteers from both sexes.

2. Have signed and dated Informed Consent.

3. Willing and able to comply with the protocol for the duration of the trial.

Exclusion Criteria:

1. Anamnesis of pharyngoesophageal dysfunction

2. Known history of cardiac, pulmonary or neurological disease

3. Ongoing medication

4. Allergies to or history of reaction to naloxone, remifentanil, fentanyl analogues or metoclopramide

5. Pregnancy or breast feeding

6. BMI > 30

7. Previous participation in a medical clinical trial where opioid has been used or have during last 30 days participated in any other medicinal clinical trial or in a trial where follow-up in not completed.