Opioid Free Anesthesia in Obese Patients.

• Status: Not yet recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Using opioids in the clinical practice of anesthesia was astonishing. They are good analgesics and used widely to modulate perioperative pain, but analgesia with these drugs can be associated with many side effects that may lead to prolongation of hospital stay and recovery period like respiratory depression, delirium, impaired gastrointestinal function, urine retention, post-operative nausea and vomiting (PONV), and addiction. The most significant opioid side effect is respiratory depression. This is especially important in patients suffering from obesity. Obese patients already have a restrictive lung disease leading to decrease in functional residual capacity and total lung compliance. Anesthetics and analgesics specially opioids make these respiratory problems become worse with increasing the incidence of hypoxia. These side effects can be avoided by using opioid free anesthesia (OFA) techniques.

Opioid free anesthesia recently become more applicable and popular in different centers, it provides pain control with marked reduction in opioid consumption. However, researches and studies still unable to explore definite explanations or techniques regarding it. The base of OFA is that not only one drug can replace opioids. It is a multimodal anesthesia. Multiple drugs are used to achieve it. They are hypnotics,N-methyl-D-aspartate (NMDA) antagonists (ketamine, magnesium sulfate), sodium channel blockers (local anesthetics), anti-inflammatory drugs (NSAID, dexamethasone), and alpha-2 agonists (dexmedetomidine, clonidine). Regional anesthesia and nerve blocks also have a role. In this study, using OFA the investigators are hoping to achieve a good quality of care to obese patients helping in fast track surgery with less complications and so shorter period of hospital stay

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fayoum University Hospital
• Treatments: Dexamethasone; Dexmedetomidine; Fentanyl; Ketamine; Lidocaine; Propofol

Criteria

Inclusion Criteria:

• American Society of Anesthesiologist (ASA) physical status Ⅱ , Ⅲ.

• body mass index (BMI) ≥30 kg/m2.

• Have upper limb surgeries (orthopedics, plastic,…) under general anesthesia.

Exclusion Criteria:

• Known allergy to the drugs will be used in the study.

• Pregnancy and lactation.

• Addiction or recent use of opioids'

• Patients will not be able deal with visual analog score(VAS).

• Hepatic, Renal and cardiac diseases in advanced stages.

• History of epilepsy or seizures.

• Patients with cerebrovascular disease.