Opioid Free Anesthesia in Prolonged Surgery

• Status: Not yet recruiting
• Trial end date: 2022-08-15
• Target enrollment: 0
• Participant gender: All

Summary

this study is designed to compare intrathecal bolus of bupivacaine-dexmedetomidine versus continuous epidural fentanyl infusion in providing effective operative analgesia, intraoperative hemodynamic stability and less postoperative cumulative opioid induced complications in orthotopic urinary bladder diversion prolonged surgery.

The hypothesis Intrathecal bolus of bupivacaine-dexmedetomidine could replace continuous epidural fentanyl infusion and would be an enough intraoperative analgesic modality with good intraoperative hemodynamic stability and less postoperative complications in orthotopic urinary bladder diversion patients.

Aim of the work The aim of this protocol is to document that intrathecal bolus of bupivacaine-dexmedetomidine analgesia (a low coast analgesic modality) can replace continuous epidural fentanyl infusion analgesic modality with effective operative analgesia, intraoperative hemodynamic stability and less postoperative cumulative opioid induced complications in orthotopic urinary bladder diversion prolonged surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

1. Patients scheduled for orthotopic urinary bladder diversion prolonged surgery procedures.

2. American society of Anaethesiologists (ASA I-II).

3. Both sexes.

4. Age 18 - 70 years.

Exclusion Criteria:

1. Patient refusal.

2. Hypersensitivity to amide local anesthetics or opioids as fentanyl.

3. General contraindications to spinal and epidural anaesthesia as thrombocytopenia, coagulopathy and severe dehydration.

4. Uncompensated Cardiac or hepatic patients.

5. Renal failure or respiratory failure patients.