Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery

• Status: Not yet recruiting
• Trial end date: 2023-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients undergoing 1-3 level Anterior Cervical Discectomy and Fusion (ACDF) at the levels between C2 and T1 will be enrolled into this randomized prospective study. All patients enrolled in this study will undergo a trial of non-surgical treatment prior to the recommendation for surgery. After enrollment, patients will be randomized utilizing a block randomization strategy to one of two treatment groups - a standard opioid-containing postoperative pain regimen versus a non-opioid postoperative pain regimen. Postoperative outcomes will be assessed.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vanderbilt University Medical Center
• Collaborator: Cervical Spine Research Society
• Treatments: Analgesics; Analgesics, Opioid

Criteria

Inclusion Criteria:

• Radiographic evidence of degenerative cervical spine disease

• Failure of conservative therapy

• Age ≥18 years

• Skeletal maturity.

Exclusion Criteria:

• Preoperative chronic opioid use as determined by review of the CSMD (>45 out of past 90 days) or self-report

• History of chronic kidney disease

• Revision cervical spine surgery

• Concurrent posterior cervical fusion