Opioid Rotation Versus Combination for Chronic Uncontrolled Cancer Pain

• Status: Completed
• Trial end date: 2007-04-01
• Target enrollment: 0
• Participant gender: All

Summary

For cancer patients with inadequate pain relief, a switch to an alternative opioid is the preferred option for symptomatic improvement. However, multiple opioids are often simultaneously administered for anecdotal reasons.

The present study isdesigned to assess the analgesic profiles of two different strategies in chronic cancer pain: the opioid rotation from oxycodone to transdermal fentanyl and the combination of oral oxycodone and transdermal fentanyl.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Gachon University Gil Medical Center
• Treatments: Fentanyl; Oxycodone

Criteria

Inclusion Criteria:

• Chronic Uncontrolled Pain That Required Stronger Opioid Therapy Than They Have Been Taking

• Histologically Confirmed Solid Cancer

• Aged Over 18 Years

• Admitted in a Palliative Cancer Care Unit

Exclusion Criteria:

• Uspected to Have Narcotic Abuse, Clinically Relevant CO2 Retention or Had an Active Skin Disease

• Inability to swallow oral medication, and impaired sensory or cognitive function

• Patients who had an active infection, uncontrolled central nervous system involvement, or on antitumor therapy of any kind