Opioid-Sparing Analgesia After Total Knee Arthroplasty
Status:
Not yet recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
The objective of this phase 2 study is to investigate the efficacy of Dexamethasone sodium
phosphate (DEX) plus Methylprednisolone acetate (MPA) in combination with plain bupivacaine
(B) compared with Liposomal Bupivacaine (LB) in combination with plain bupivacaine on
post-surgical pain control among patients undergoing unilateral total knee arthroplasty (TKA)
to asses if perineural B-DEX-MPA will result in superior analgesia efficacy as compared to
B-LB.
This study will also assess if perineural B-DEX-MPA results in improved quality of
postoperative recovery as compared to B-LB.
Phase:
Phase 2
Details
Lead Sponsor:
Yale University
Collaborator:
Department of Anesthesiology Faculty Development Fund