Optimal Anesthesia for Morbidly Obese Patients

• Status: Active, not recruiting
• Trial end date: 2022-06-30
• Target enrollment: 0
• Participant gender: All

Summary

Obese patients have a higher risk of anesthesia compared to the non-obese, including difficult intubation, rapid desaturation, difficult vascular access, and delayed recovery from anesthesia. This study aims to investigate the optimal anesthesia strategy for morbidly obese patients undergoing bariatric surgery in airway management, preoxygenation, arterial cannulation, and type of volatile anesthetic with M-Entropy guidance. The investigators will conduct a two-year clinical trial using permuted block randomization to evaluate multiple outcomes in patients undergoing laparoscopic sleeve gastrectomy (LSG) at Shuang Ho Hospital, Taipei Medical University. Particularly, the investigators will explore the role of ultrasound, an easily accessible modality for anesthesiologists, in examining upper airway anatomy and guiding arterial cannulation. The investigators will also assess the effectiveness of high-flow nasal cannula as a preoxygenation tool in preventing desaturation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Taipei Medical University Shuang Ho Hospital
• Collaborator: Ministry of Science and Technology, Taiwan
• Treatments: Anesthetics

Criteria

Inclusion Criteria:

• Age 20 to 65 years

• BMI ≥ 30 kg/m2

• Undergoing laparoscopic sleeve gastrectomy at Shuang-Ho Hospital, Taiwan

Exclusion Criteria:

• Severe cardiopulmonary disease

• Psychiatric disorder

• History of head and neck surgery or radiation therapy

• Cervical spine injury

• Renal insufficiency (estimated creatinine clearance < 60 ml/min)

• SpO2 < 90% in room air

• Hemodynamic instability

• Preexisting arterial catheterization during the same visit within 7 days

• Patient refusal