Optimal Dose of Intravenous Oxycodone for Endotracheal Intubation
Status:
Completed
Trial end date:
2017-02-12
Target enrollment:
Participant gender:
Summary
Intravenous form of oxycodone is recently used for the adjunct of anesthetic agents to avoid
adverse effects of the stimulation of endotracheal intubation. The potency ratio of oxycodone
to fentanyl is not absolutely defined. The aim of this study was to assess the optimal dose
of intravenous oxycodone for attenuation of hemodynamic responses to laryngoscopy and
endotracheal intubation.
A prospective, randomized, double-blind study was conducted. Ninety one patients were
randomly divided into 5 group based on the dose of oxycodone; 0, 0.05, 0.1, 0.15, 0.2 mg/kg.
After giving each assigned dose of intravenous oxycodone, anesthesia was induced with
thiopental and rocuronium. Heart rate (HR) and blood pressure (BP) was collected at baseline,
before intubation, 1, 2, 3 minutes after intubation. The change of BP was calculated by
(highest BP after intubation - baseline BP)/baseline BP.