Optimal Dose of Intravenous Oxycodone for Endotracheal Intubation

• Status: Completed
• Trial end date: 2017-02-12
• Target enrollment: 0
• Participant gender: All

Summary

Intravenous form of oxycodone is recently used for the adjunct of anesthetic agents to avoid adverse effects of the stimulation of endotracheal intubation. The potency ratio of oxycodone to fentanyl is not absolutely defined. The aim of this study was to assess the optimal dose of intravenous oxycodone for attenuation of hemodynamic responses to laryngoscopy and endotracheal intubation.

A prospective, randomized, double-blind study was conducted. Ninety one patients were randomly divided into 5 group based on the dose of oxycodone; 0, 0.05, 0.1, 0.15, 0.2 mg/kg. After giving each assigned dose of intravenous oxycodone, anesthesia was induced with thiopental and rocuronium. Heart rate (HR) and blood pressure (BP) was collected at baseline, before intubation, 1, 2, 3 minutes after intubation. The change of BP was calculated by (highest BP after intubation - baseline BP)/baseline BP.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yong-Hee Park
• Collaborator: Chung-Ang University
• Treatments: Oxycodone

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) class 1

Exclusion Criteria:

• ASA class over 2

• expected difficult intubation

• intubation time over 30 seconds

• intubation trial was more than once