Optimal Dose of Omeprazole After Endoscopic Treatment of Bleeding Peptic Ulcers

• Status: Completed
• Trial end date: 2007-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Bleeding peptic ulcers are one of the major causes of morbidity and mortality for hospital emergency admissions.The initial treatment is endoscopic therapy followed by intravenous omeprazole. However the optimal dosage of omeprazole is not known. We conducted this study to find out the optimal dosage in such clinical scenario.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Singapore General Hospital
• Treatments: Omeprazole

Criteria

Inclusion Criteria:

1. Above 21 year old

2. OGD done within 48 hrs of admission

3. No recent upper GIT surgery past one month

4. Forrest Type I, IIa & IIb ulcer (Type Ia: Spurting, Ib:Oozing, IIa: Visible vessel, IIb: Clot)

5. Non-malignant ulcer

6. Informed consent taken

Exclusion Criteria:

1. Impaired hepatic function

2. Pregnancy

3. Lactation

4. Concomitant medication (warfarin, diazepam, phenytoin, chlarithromycin, cimetidine and digoxin)

5. Underlying malignancy