Optimal Dose of Proton Pump Inhibitors Following an Upper Gastrointestinal Bleed
Status:
Terminated
Trial end date:
2015-08-17
Target enrollment:
Participant gender:
Summary
Despite recommendations from clinical practice guidelines to discharge patients from the
hospital on once daily proton pump inhibitors after acute management of UGIB, clinical
practice is to use twice daily proton pump inhibitor therapy. The objective of this study
will be to assess whether or not once daily pantoprazole is non-inferior to twice daily
pantoprazole in ulcer healing with a dose of once daily versus twice daily proton-pump
inhibitor following an upper gastrointestinal bleed. Additionally, this study will observe
for any potential difference in safety for once daily versus twice daily proton pump
inhibitors.