Optimal Dosing of Preoperative Gabapentin for Prevention of Postoperative Nausea and Vomiting

• Status: Completed
• Trial end date: 2021-02-15
• Target enrollment: 0
• Participant gender: All

Summary

Overall incidence of postoperative nausea and vomiting (PONV) after general anesthesia is 40-90 % . gabapentin has been incorporated into "fast-track" packages and improved recovery during surgery protocols to avoid unintended side effects associated with opioid alternatives. Interestingly, gabapentin has also been noted to reduce the effects of chemotherapy-induced nausea, effective in treatment of gravidarum hyperemesis, and postdural puncture emesis. Different dosing regimens were tested.The goal of the study is to determine the most effective dose of oral gabapentin given 1 hour prior to surgery on the occurrence and severity of PONV and drug side effects in the first 24 hours postoperatively to find the most effective dose of gabapentin with the least side effects.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Gabapentin

Criteria

Inclusion Criteria:

• age between (18- 65) years

• ASA I-II

• scheduled for elective laparoscopic abdominal surgery.

Exclusion Criteria:

• age below 18 and above 60 years

• ASA III- IV

• pregnancy or breastfeeding

• psychiatric illness

• administration of antiemetic or systemic corticosteroids within 24 hours prior to surgery

• vomiting within 24 hours prior to surgery

• alcohol or drug abuse;

• known hypersensitivity or contraindications to gabapentin

• impaired liver or kidney function

• history of motion sickness

• patients on anti-depressants

• patients on whom laparoscopic procedure converted into open technique.