Optimal Duration of Dual Antiplatelet Therapy After Drug-eluting Stent Implantation

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare treatment with aspirin alone versus the combined antiplatelet treatment aspirin and clopidogrel after 12 months of combined antiplatelet treatment following drug-eluting stent (DES) implantation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Collaborator: Fédération Française de Cardiologie
• Treatments: Aspirin; Clopidogrel; Ticlopidine

Criteria

Inclusion can be done either after stenting or 12 months later :

A: Patients admitted for DES implantation can be selected. After 12 months of bi therapy, they will be randomized

B: patients who have got a DES implantation 12 months before can be selected and randomised

Inclusion criteria:

• Patients on aspirin and clopidogrel therapy at 12 months after DES implantation

• Informed, written consent by the patient

Exclusion criteria:

• DES in left main coronary artery

• Oral anticoagulation therapy with coumadin derivatives

• Active bleeding; bleeding diathesis; history intracranial bleeding

• Known allergy or intolerance to the study medications: aspirin and clopidogrel

• Pregnancy (present, suspected or planned) or positive pregnancy test (In women with childbearing potential a negative pregnancy test is mandatory)

• Patient's inability to fully comply with the study protocol