Overview

Optimal Timing of Intercostal Nerve Blocks During Video-Assisted Thoracic Surgeries

Status:
Unknown status
Trial end date:
2021-09-30
Target enrollment:
0
Participant gender:
All
Summary
Intercostal nerve block, performed under the guidance of videoscope, is a part of standard anesthesia procedures for patients receiving Video-Assisted Thoracic Surgeries. In this double-blind, prospective, multi-center, randomized, controlled clinical trial the investigators aim to compare preemptive versus post-closure intercostal injection of ropivacaine in controlling post-video-assisted thoracotomy pain.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University at Buffalo
Collaborators:
The VA Western New York Healthcare System
Veteran Affairs Western New York Healthcare System
Treatments:
BB 1101
Dexamethasone
Dexamethasone 21-phosphate
Dexamethasone acetate
Epinephrine
Epinephryl borate
Racepinephrine
Ropivacaine
Criteria
Inclusion Criteria:

Patients will be eligible to enroll in this study if they:

- Have physical status within ASA class II or III

- Are between 18 and 85 years of age

- Are candidates for VATS

- Are able to complete VAS assessments

- Are competent to sign the informed consent form

Exclusion Criteria:

Patients will not be enrolled in this study if they:

- Are pregnant

- Have allergy to ropivacaine or hydromorphone

- Have renal insufficiency (eGFR<60mL/min/1.73m2)

- Have hepatic insufficiency (AST, ALT, or both >60 U/L) or cirrhosis

- Have a predicted postoperative forced vital capacity (FVC) of <40%, predicted forced
expiratory volume at 1s (FEV1) <40%

- Have coagulopathy (platelet count<50000, INR>2, or both)

- Have a history of opioid addiction, chronically taking opioids, currently taking high
dose of opioids or currently taking opioid agonist+antagonist (e.g. Suboxone®)

- Are taking nonsteroidal anti-inflammatory drug, including aspirin, within a week prior
to surgery (since the analgesic effects of NSAID drugs may become confounding
factors).