Optimisation of Follicular Recruitment in IVM Cycles
Status:
Recruiting
Trial end date:
2022-02-28
Target enrollment:
Participant gender:
Summary
The study will focus on important aspects related to follicle recruitment using exogenous
gonadotropins in patients with polycystic ovaries:
1. Early follicle recruitment in patients with polycystic ovaries using corifollitropin
alfa: does administration of this drug result in earlier and higher FSH (follicle
stimulating hormone) concentrations above the threshold for follicle recruitment in an
IVM (in vitro maturation) cycle preceded by oral contraceptive suppression, in
comparison to normal daily administration of rFSH (recombinant follicle stimulating
hormone, Puregon)?;
2. The maturation rate of the obtained oocyte-cumulus complexes in standard IVM media
registered for clinical use: does stimulation with corifollitropin alfa versus
recombinant FSH have an impact on the maturation rate and developmental capacity of the
oocytes ?