Optimised Fluoride Prevention by Double Rinse With Fluoride and Calcium

• Status: Completed
• Trial end date: 2012-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Aim: to determine the optimal Ca2+ concentration with 905 ppm F as NaF. Study design:

Experimental study in 10 volunteers. Single blind mouth rinse with calcium lactate solution (150; 75; 0 mM Ca-lactate) is immediately followed by a standard fluoride rinse.

Procedure: Rinses are performed in the evening. The rinse combinations are given in a random order, and the subjects are unaware of the sequence. At least 3 days separates the use of each rinse. Dosage: 20 mL and 1 minute rinse with each solution.

Saliva samples: Twelve hours after rinsing, unstimulated saliva samples are collected by expectoration.

Analysis: The fluoride concentration in saliva samples are analysed Statistics and data handling: Fluoride in saliva 12 hours after rinsing are examined by one-way ANOVA, repeated measures design.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Karolinska Institutet
• Treatments: Calcium; Calcium, Dietary; Fluorides; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• 18 years or older

• 10 natural teeth or more

• willing to refrain from use of fluoride containing products

• signed informed consent

Exclusion Criteria:

• less than 10 natural teeth

• reduced cognitive skills

• does not speak and/or understand Swedish

• ongoing oral or systemic infections

• pregnancy

• breast feeding