Optimising Antibiotic Treatment for Sick Malnourished Children
Status:
Unknown status
Trial end date:
2017-09-30
Target enrollment:
Participant gender:
Summary
Children with severe malnutrition who are admitted sick to hospitals have a high mortality,
usually because of infection. All children with severe malnutrition admitted to hospitals are
treated with antibiotics. However, policymakers are not sure that the current antibiotics are
the most effective. It is possible that the antibiotics that are currently used as
second-line should be used first. Finding this out will need a large trial comparing
different antibiotics. To prepare for such a trial the investigators first want to make sure
that the doses given are correct for malnourished children. The investigators also want to
check whether malnourished children more commonly carry resistant bacteria in their feces
than well-nourished children. The study is important because the types of antibiotics and the
doses needed to fight infection may be different in malnourished children because of the
changes in their body due to malnutrition and the types of bacteria present.
Phase:
Phase 2
Details
Lead Sponsor:
University of Oxford
Collaborators:
Centre for Clinical Research, Kenya Medical Research Institute Centre for Microbiology Research, Kenya Medical Research Institute Centre for Research in Therapeutic Sciences, Strathmore University, Nairobi Kenya KEMRI Wellcome Trust Research Program, Kenya KEMRI-Wellcome Trust Collaborative Research Program University College, London