Optimization of Contrast Agent Dose in CT With Lean Body Weight

• Status: Completed
• Trial end date: 2019-02-25
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the different enhancement using a contrast agent dose in computed tomography based on total body weight or based on lean body weight. Half of participants will receive contrast agent dose based on their total body weight, while the other half will receive a dose based on their lean body weight. Our hypothesis is that if contrast agent is administered not basing on total body weight but on lean body weight it is possible to obtain equal or better quality of enhanced images, a reduction of the variability of contrast enhancement, and also a dose reduction in some patients (overweight ones).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: IRCCS Policlinico S. Donato

Criteria

Inclusion Criteria:

• Patient ≥ 18 years of age;

• Patients who will perform a contrast-enhanced abdominal CT multi-phasic in our institutions;

• Patients able to give informed consent.

Exclusion Criteria:

• history of chronic underlying liver disease (cirrhosis, fatty infiltration of the liver, or glycogen storage disease);

• history of chronic underlying heart disease (congestive heart failure, prior cardiac valve replacement, restrictive and/or constrictive pericarditis);

• multiple myeloma;

• hypersensitivity to iodine-containing compounds;

• renal insufficiency (serum creatinine level ≤ 1.8 mg/dL [159.12 µmol/L]) or patients with renal failure (eGR <30 ml/min/1.73 m2);

• patients with antecubital vein that, at medical evaluation, cannot sustain the flow rate of CA injection (see below);

• patients carrier of prosthesis or metal bullets, pacemaker or stimulators;

• patients with liver diseases that affect the entire parenchyma;

• fragile patients which, after radiologist evaluation, require lower dose of CA;

• pregnancy;

• general contraindications to CT examination or reasoned decision of the radiologist.