Optimization of MDR-TB Treatment Regimen Based on the Molecular Drug Susceptibility Results of Pyrazinamide
Status:
Unknown status
Trial end date:
2016-04-01
Target enrollment:
Participant gender:
Summary
Multidrug resistant tuberculosis (MDR-TB) is difficult to treat and raises a great challenge
to TB control program. That pyrazinamide can shorten the course of treatment and facilitate
bacilli clearance has been proved recently. In 2011, WHO recommended to use pyrazinamide
throughout the course of treatment for MDR-TB. However, pyrazinamide susceptibility testing
has not been widely used in clinic. And the conventional testing is time-consuming and
unreliable. In contrast, the detection of pncA and rpsA mutations with molecular methods can
provide rapid results of pyrazinamide susceptibility. The purpose of this study is to
evaluate the efficacy of the introduce the molecular testing of pyrazinamide susceptibility
in optimizing the MDR-TB treatment regimen.