Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
Approximately 3,500 people will participate per year. The study population will include
females and males over 5 years of age who live in filariasis endemic areas. The study will be
performed in Indonesia in B. timori and W. bancrofti endemic areas over a period of 4 years.
Participants will be studied only once in cross-sectional surveys. Some subjects may be
included in more than one annual population survey, but this is not a longitudinal study.
Purpose of the study is to evaluate different mass drug administration (MDA) regimens for
lymphatic filariasis and also to study the impact of MDA on soil transmitted helminth
infections (STH). MDA will administered by others (e.g., Ministry of Health). Results of this
study may enhance efforts to control and eliminate these important neglected tropical
diseases.
The investigators will test the hypothesis that accelerated mass drug administration will be
superior to annual MDA for elimination of lymphatic filariasis and for control of soil
transmitted helminth infections (STH):
1. Compare the relative impact and cost effectiveness of annual vs. twice yearly mass drug
administration (MDA) for elimination of lymphatic filariasis (LF).
2. Study the impact of annual vs. semiannual MDA on soil transmitted helminth (STH)
infection in these populations.