Optimization of Sedation Protocol for Endoscopic Procedures Using Impedance Ventilation Monitor.
Status:
Recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
The aim of the study is to evaluate the effect of opioids administered during sedation on
patients' respiratory activity (ventilation) and comfort of the operator and patient during
the endoscopic procedure. A common side effect of sedation is the effect on patients'
ventilation, resulting from a combination of attenuation of respiratory centre activity and
loss of patent airways. Shallow sedation will reduce these risks, but in addition to patient
discomfort, it also increases the difficulty or impossibility of the endoscopist to perform
the procedure. Choosing the appropriate method of sedation thus fundamentally affects the
course of the procedure from the point of view of both the patient and the endoscopist. The
aim is to prove that sedation with propofol alone compared to sedation with propofol and
fentanyl premedication leads to the need for higher cumulative doses of administered
propofol, higher risk of respiratory depression and lower patient and operator comfort. In
addition, the non-invasive respiratory volume monitor (ExSpiron 2Xi) will be used for
standard patient monitoring during the procedure, which assesses the lung tidal volume and
respiratory rate by measuring the electrical impedance of the chest. This measurement
captures inadequate ventilation before saturation drops, allowing even slight differences
between selected drugs to be compared.