Optimization of Therapeutic Human Serum Albumin Infusion in Selected Critically Ill Patients

• Status: Terminated
• Trial end date: 2019-08-10
• Target enrollment: 0
• Participant gender: All

Summary

Primary purpose : mortality at Day 28

Secondary purposes :

• Daily SOFA (Sequential Organ Failure Assessment) score lessening within Intensive Care Unit (ICU)

• Duration of increasing doses of norepinephrine infusion to maintain target mean arterial pressure

• Number of care-related infections within ICU

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Strasbourg, France
• Treatments: Norepinephrine

Criteria

Inclusion Criteria:

• circulatory failure requiring norepinephrine support (any dose)

• hospitalization within an Intensive Care Unit

• SIRS

• low plasma albumin (< 20g/L)

• consent to study

Exclusion Criteria:

• absence of circulatory failure

• absence of SIRS

• chronic low albumin concentration

• absence of consent to study

• inability to tolerate human serum albumin

• Patients under guardianship or curators

• Women pregnant