Optimization of Treatment and Management of Schizophrenia in Europe (OPTIMISE): Substudy Site Copenhagen
Status:
Completed
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
The investigators want to relate disturbances in first-episode schizophrenic patients in
(dopaminergic) D2 receptors, brain structure, brain function, and information processing to
each other and to psychopathology. Additionally, the investigators want to examine the
influence of D2 receptor blockade on these disturbances. The investigators expect
disturbances in the dopaminergic system at baseline to correlate with specific structural and
functional changes and with disruption in information processing as measured with
psychophysiological and neurocognitive methods - and investigators expect D2 receptor
blockade to reverse some of the functional and cognitive impairments. The investigators do
not expect any effect of treatment on brain structure.
Phase:
N/A
Details
Lead Sponsor:
Birte Glenthoj
Collaborators:
Copenhagen Hospital Corporation Glostrup University Hospital, Copenhagen Institute of Psychiatry, London Rigshospitalet, Denmark UMC Utrecht