Optimization of the Primary Therapy for Patients With Hodgkin's Disease and Evaluation of PET

• Status: Unknown status
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Prognosis of patients with Hodgkin´s lymphoma (HL) has been improved significantly over the last decade. Therefore, the impact of treatment associated long-term toxicities and late effects such as second cancers increased. The purpose of this prospective multicenter trial is to show the feasibility of the treatment with ABVD alone in patients with limited stage (HL1) and intermediate stage (HL2) disease and of an intensified etoposide-free chemotherapy regimen for patients with advanced disease (HL3) including 18F-FDG-PET evaluation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Carl Gustav Carus
• Collaborator: Technische Universität Dresden

Criteria

Inclusion Criteria (HL1):

• Histologically confirmed Hodgkin´s Lymphoma (WHO Classification 1999)

1. Classical Hodgkin Lymphoma: Nodular sclerosis (type 1 and 2) / Mixed type / Lymphocyte depleted type / Lymphocyte rich type

2. Nodular lymphocyte-predominant Hodgkin Lymphoma

• Patients in stage: Clinical stage (CS) I without risk factors / CS II without risk factors

• Age between 16 and 75

• Written informed consent

Inclusion criteria (HL2):

• Histologically confirmed Hodgkin´s Lymphoma (WHO Classification 1999)

1. Classical Hodgkin´s Lymphoma: Nodular sclerosis (type 1 and 2) / Mixed type / Lymphocyte depleted type / Lymphocyte rich type

2. Nodular lymphocyte-predominant Hodgkin Lymphoma

• Patients in stage

1. Clinical stage (CS) I,II A with risk factors: Large mediastinal tumor (>1/3 of the maximal diameter of the thoracic cavity) / Extranodal disease / Sedimentation rate ≥ 50 mm/h for patients without B-symptomes or ≥ 30 mm/h for patients with B-symptomes / ≥ 3 lymph node areas infiltrated with tumor cells

2. Clinical stage (CS) II B with risk factors: Sedimentation rate ≥ 50 mm/h for patients without B-symptomes or ≥ 30 mm/h for patients with B-symptomes / ≥ 3 lymph node areas infiltrated with tumor cells

• Age between 16 and 75

• Written informed consent

Inclusion criteria (HL3):

• Histologically confirmed Hodgkin´s Lymphoma (WHO Classification 1999)

1. Classical Hodgkin's Lymphoma (Hodgkin's desease): Nodular sclerosis (type 1 and 2) / Mixed type / Lymphocyte depleted type / Lymphocyte rich type

2. Nodular lymphocyte-predominant Hodgkin Lymphoma

• Patients in stage

1. Clinical stage (CS) II B with minimum one of the following risk factors: Large mediastinal tumor (≥1/3 of the maximal diameter of the thoracic cavity) / Extranodal disease

2. Clinical stage (CS) III

3. Clinical stage (CS) IV

• Age between 16 and 65

• Written informed consent

Exclusion Criteria (HL1, HL2 and HL3):

• Poor general condition not related to the lymphoma (ECOG perfomance status 3 or 4; Karnofsky Index < 50 %)

• Severe concomitant diseases: cardiac insufficiency (NYHA grade III or IV) / chronic respiratory insufficiency with hypoxemia / Hepatic insufficiency (cirrhosis, Hepatitis B or C / chronic renal insufficiency / HIV infection or other out-of-control infections / hematopoetic insufficiency (Leukocytes < 3000/µl; Thrombocytes < 100.000/µl / psychiatric diseases

• History of previous malignancy in the last 5 years

• Pregnancy

• Patients not likely to comply to the requirements stemming form the participation in the trial