Hypothesis: Optimal anticoagulation defined as an Activated Clotting Time (ACT) of 300 to 350
seconds obtained by weight-adjusted doses of unfractionated heparin (UFH) will improve the
hemostatic environment downstream from the vascular clamp, provide better blood flow in the
distal bed following peripheral revascularization surgery.
Objectives: This study is designed to assess the effects of an optimized regimen of UFH on
the hemostatic environment downstream from the vascular clamp in major vascular surgery.