Optimized Heparin Regimen in Vascular Surgery

• Status: Completed
• Trial end date: 2016-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Hypothesis: Optimal anticoagulation defined as an Activated Clotting Time (ACT) of 300 to 350 seconds obtained by weight-adjusted doses of unfractionated heparin (UFH) will improve the hemostatic environment downstream from the vascular clamp, provide better blood flow in the distal bed following peripheral revascularization surgery.

Objectives: This study is designed to assess the effects of an optimized regimen of UFH on the hemostatic environment downstream from the vascular clamp in major vascular surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)
• Treatments: Anesthetics; Calcium heparin; Heparin; Polystyrene sulfonic acid

Criteria

Inclusion Criteria:

• Patients undergoing elective revascularization surgery

• American Society of Anesthesiologists (ASA) physical status l-lll inclusive

Exclusion Criteria:

• Known or suspected allergy to heparin or protamine

• Contraindication to heparin or protamine

• Known or suspected coagulopathy

• Current anticoagulation or residual effect of anticoagulants, antiplatelet agents, except aspirin