Optimizing Early Enteral Nutrition in Severe Stroke

• Status: Terminated
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this academic lead study is to explore the ideal nutritional support strategy for patient with acute severe stroke.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xijing Hospital
• Collaborators: Ankang Central Hospital; First Affiliated Hospital Xi'an Jiaotong University; Hanzhong Central Hospital; Shaanxi Provincial People's Hospital; Tang-Du Hospital; The First Affiliated Hospital of Xi'an Medical University; The First People's Hospital of Xianyang; The PLA 940 hospital; The PLA General Hospital of Xinjiang; Tongchuan Mining Hospital; Tongchuan People's Hospital; Xi'an Central Hospital; Xi'an Gaoxin Hospital; Xi'an No.3 Hospital; Yan'an University Affiliated Hospital; Yulin No.1 Hospital; Yulin No.2 Hospital
• Treatments: Erythromycin; Erythromycin Estolate; Erythromycin Ethylsuccinate; Erythromycin stearate; Metoclopramide; Mosapride

Criteria

Inclusion Criteria:

• Severe stroke occurred in 7 days.

• GCS ≤12 or NIHSS≥11.

• Any cases of profiles #3 through 5 in Water Swallowing Test or with disorder of consciousness.

• Plan to receive enteral feeding for at least 7 days.

• Informed consent.

Exclusion Criteria:

• Gastrointestinal diseases before stroke, such as gastrointestinal resection, malabsorption,and irritable bowel syndrome.

• Brain death.

• Complicated with the disease which only have life expectancy < 6 months in over 50% patients.

• After cardiac arrest.

• Received parenteral nutrition support.

• Pregnant woman.

• Concurrent severe hepatic or renal dysfunction。

• Unstable hemodynamics.