Overview Optimizing Outcomes of Treatment-Resistant Depression in Older Adults Status: Recruiting Trial end date: 2021-12-01 Target enrollment: Participant gender: Summary The purpose of this research study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD). Phase: Phase 4 Details Lead Sponsor: Washington University School of MedicineCollaborators: National Institute of Mental Health (NIMH)Patient-Centered Outcomes Research InstituteTreatments: Antidepressive AgentsAripiprazoleBupropionLithium CarbonateNortriptyline