An accurate dosage of anesthetics during surgery is important. Usually this is achieved
through close observation of the patient, but a new monitor (CSM-monitor) can measure the
level of anesthesia more closely.
In obese patients dosage of drugs is difficult due to the change in body composition. The
CSM-monitor may provide a more accurate dosage of propofol (an anesthetic agent) during
surgery, and as a consequence of that, also reduce the postoperative need for analgesics.
Main objective: To optimise propofol dosing in obese patients undergoing hysterectomy.
Main hypothesis: Monitoring the depth of anesthesia using the CSM-monitor reduces time to
opening eyes in obese patients after hysterectomy in propofol anesthesia.
Secondary hypotheses: CSM-monitoring reduce propofol dose in obese patients undergoing
hysterectomy. Patients with a high CSM-level during hysterectomy have higher postoperative
consumption of analgesics. Supplementary, an algorithm for the dose of propofol that most
frequently results in a CSM-level between 40 and 60 is calculated.