Optimizing Surgical Conditions During Gynecologic Laparoscopic Surgery With Deep Neuromuscular Blockade

• Status: Completed
• Trial end date: 2014-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

To investigate if deep neuromuscular blockade improves intraabdominal volume compared to no neuromuscular blockade in patients scheduled for gynecologic laparoscopic surgery with pneumoperitoneum 12 mmHg.

Hypothesis:

Deep neuromuscular blockade improves intraabdominal space (the distance from promontorium to skin surface, cm) compared to no neuromuscular blockade.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Herlev Hospital
• Treatments: Rocuronium

Criteria

Inclusion Criteria:

• patients > 18 years old

• elective laparoscopic operation

• can read and understand Danish

• informed consent

Exclusion Criteria:

• BMI > 30 kg/cm2

• known allergy to medications that are included in the project,

• severe renal disease, defined by S-creatinine> 0,200 mmol/L, GFR < 30ml/min or hemodialysis),

• neuromuscular disease that may interfere with neuromuscular data,

• lactating or pregnant,

• impaired liver function,

• converting to laparotomy,

• perioperative use of neuromuscular blocking agents before randomization,

• pneumoperitoneum set to >12 mmHg on the insufflator