Oral Amantadine Versus Gabapentin to Attenuate the Response to Laryngoscopy and Tracheal Intubation

• Status: Completed
• Trial end date: 2018-05-15
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate the effect of oral amantadine versus gabapentin premedication on the hemodynamic response to laryngoscopy and tracheal intubation and their effect on β-endorphins.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ghada Mohammed AboelFadl
• Treatments: Amantadine; Endorphins; Gabapentin; gamma-Aminobutyric Acid

Criteria

Inclusion Criteria:

• ASA I&II scheduled for elective spine surgery

Exclusion Criteria:

• Patient refusal

• Patients with ASA score III (with chronic kidney, lungs, Gastrointestinal tract, liver, or cardiovascular diseases)

• Pregnant or breastfeeding women.

• Allergy to any of the study medications and taking medications that could significantly interact with amantadine (tramadol, atropine, antipsychotic medications)

• diabetes mellitus, thyroid disease any endocrine disease

• Suspected difficult intubation or intubation time more than 30 second.