Oral Aprepitant and Lower Dose Dexamethasone Versus Aprepitant Alone for Preventing Postoperative Nausea and Vomiting (PONV) After Elective Laparoscopic Surgeries

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The combination of aprepitant and lower dose dexamethasone is superior to aprepitant alone with respect to the proportion of patients with a complete response (no vomiting and no use of rescue therapy) during 24 hours after the placement of last suture/staple.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Main Line Health
• Collaborators: Drexel University College of Medicine; Merck Sharp & Dohme Corp.
• Treatments: Aprepitant; BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Fosaprepitant

Criteria

Inclusion Criteria:

• at least 18 years old

• ASA physical status I-III

• must have at least 2 risk factors for PONV

Exclusion Criteria:

• pregnant or breast feeding patients

• antiemetic medication in previous 24 hours

• allergy or other contraindication to study medications