Cleft lip and palate are a significant component of morbid human birth defects in the
developing world. By supplementing a high-risk group of women with folic acid (4.0 mg versus
0.4 mg) from preconception and continuing throughout the first 3 months of pregnancy in the
state of Sao Paulo, Brazil, this study aims to reduce the recurrence of cleft lip and palate.
Phase:
Phase 3
Details
Lead Sponsor:
NICHD Global Network for Women's and Children's Health
Collaborators:
Bill and Melinda Gates Foundation Fogarty International Center of the National Institute of Health Global Network for Women's and Children's Health Research Hospital de Reabilitação de Anomalias Craniofaciais (HRAC) - Brazil John E. Fogarty International Center (FIC) National Cancer Institute (NCI) National Center for Complementary and Integrative Health (NCCIH) National Institute of Dental and Craniofacial Research (NIDCR) RTI International University of Iowa