Oral Clonidine & Gabapentin: Improving Recovery and Pain Management After Outpatient With Major Orthopedic Surgery

• Status: Withdrawn
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research is to investigate the non-opioid (non-narcotic) pain-relieving medications clonidine and gabapentin to see if they decrease the amount of opioid pain medications needed after surgery, thereby reducing opioid-related side effects, and time required to return to normal activities of daily living after surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cedars-Sinai Medical Center
• Treatments: Clonidine; Gabapentin; gamma-Aminobutyric Acid

Criteria

Inclusion Criteria:

• Patients scheduled to undergo arthroscopic joint surgery

• Willingness and ability to sign an informed consent document

• No allergies to clonidine, gabapentin, anesthetic or analgesic medications

• 18 - 80 years of age

• American Society of Anesthesiologists (ASA) Class I - III adults of either sex

• Women of childbearing potential must be currently practicing an acceptable form of birth control, and have a negative urine pregnancy test

Exclusion Criteria:

• Patients with known allergy, hypersensitivity or contraindications to clonidine, gabapentin, anesthetic or analgesic medications

• Patients with clinically-significant medical conditions, such as brain, heart, kidney, endocrine, or liver diseases, peptic ulcer disease or bleeding disorders

• Patients with chronic hypertension or pain syndromes receiving clonidine or gabapentin, respectively.

• Pregnant or lactating women

• Subjects with a history of alcohol or drug abuse within the past 3 months

• Patients taking any analgesic medications within 48 hours prior to the surgery

• Any other conditions or use of any medication which may interfere with the conduct of the study

• Non-English speakers

• Patients greater than 80 years of age