Oral Colecalciferol Treatment in Spinal Cord Lesion

• Status: Completed
• Trial end date: 2021-01-04
• Target enrollment: 0
• Participant gender: All

Summary

Low vitamin D is frequently seen in patients with spinal cord injury (SCI) in acute and chronic periods. Among its causes are insufficient sun exposure, limited oral intake, obesity, the effect of the drugs used on the absorption of vitamin D, kidney and liver diseases. If we consider patients with spinal cord injuries in Turkey, it is difficult to get involved in the society, low exposure to the sun, lack of necessary health controls and immobility brings extra risk factors for the low vitamin D compared to the general population. Despite Turkey Endocrinology and Metabolism Endocrine Society and the International Endocrine Association clinical practice guidelines do not provide specific recommendations about vitamin D, for individuals with spinal cord injuries. Individuals with SCI are at high risk for low vitamin D. Vitamin D levels need to be checked and replaced. Vitamin D doses, application methods and dose intervals used in Physical Therapy and Rehabilitation clinics are different. The aim of our study is to perform the necessary vitamin D replacement for individuals with SCI who have vitamin D deficiency in different dose intervals and to compare the effects of muscle strength, muscle thickness and functional independence with the control group.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital
• Treatments: Cholecalciferol; Vitamin D

Criteria

Inclusion Criteria:

1. 18-60 years old

2. Thoracic level chronic spinal cord injury

3. A, B, C, D complete / incomplete patients according to ASIA classification

4. 25 (OH) D3 level in serum is <20 ng / ml

5. Complete muscle strength in upper extremity

Exclusion Criteria:

1. Individuals with chronic liver, kidney, respiratory and parathyroid disease

2. Chronic constipation

3. Patients who have recently used vitamin D

4. Use of drugs that will affect vitamin D and Ca level (Thiazide group diuretics, statins)

5. Acute inflammation (may show false low in vitamin D levels)