Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension

• Status: Recruiting
• Trial end date: 2023-10-13
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to see if a combined pill of Angiotensin-converting enzyme (ACE) inhibitors (a medication that helps relax your veins and arteries to lower your blood pressure) with diuretics (sometimes called water pills, help rid your body of salt and water) will control blood pressure better than a different blood pressure medication of calcium channel blocker (lower your blood pressure by preventing calcium from entering the cells of your heart and arteries). Both medications are part of our usual care for high blood pressure after delivery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Health Science Center, Houston
• Treatments: Angiotensin-Converting Enzyme Inhibitors; Diuretics; Nifedipine

Criteria

Inclusion Criteria:

• Postpartum women at ≥ 18 years of age

• Postpartum diagnosis of persistent hypertension (2 measurements of Systolic BP ≥150 and/or diastolic BP ≥ 100 or systolic BP ≥140 and/or diastolic BP ≥ 90 for people with diabetes) requiring an oral medication based on the ACOG criteria or

• Hypertensive disorder of pregnancy diagnosed antepartum or intrapartum requiring blood pressure medication in the postpartum

• Chronic hypertension requiring blood pressure medication postpartum

Exclusion Criteria:

• Urine output < 30 cc/h prior to screening for eligibility

• Creatinine > 1.4 during current admission

• End-stage renal disease

• Hypersensitivity to ACE inhibitors or sulfa drugs

• Idiopathic/hereditary angioedema

• Hyperkalemia (serum potassium >5 mEq/L) during current admission

• Pulmonary edema