Oral Contraceptives and Subantimicrobial Doxycycline: Effect on Endometrial Matrix Metalloproteinases

• Status: Completed
• Trial end date: 2012-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to compare the effects (good and bad) of subantimicrobial dose doxycycline on the irregular bleeding women experience when taking continuous oral contraceptive pills. This research is being done because currently, there is no effective treatment for this condition. Findings from this study could help to decrease the side effects of birth control pills and decrease unplanned pregnancies.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Hawaii
• Collaborators: Charles Drew University of Medicine and Science; Meharry Medical College
• Treatments: Contraceptive Agents; Contraceptives, Oral; Contraceptives, Oral, Combined; Doxycycline

Criteria

Inclusion Criteria:

• Women between the ages 18 and 45 who are ovulatory as demonstrated by a pre-treatment Progesterone (P) greater than or equal to 3.0 ng/mL prior to oral contraceptive use

Exclusion Criteria:

• Women with any absolute contraindications to ethinyl estradiol and levonorgestrel;

• Women who are pregnant or breastfeeding

• Use of oral contraceptives, patch, ring, intrauterine or implantable hormonal contraception within 4-weeks;

• Medroxyprogesterone acetate use within six months;

• Current use of drugs that interfere with sex steroid metabolism.