Oral Dexamethasone for Treatment of Migraine

• Status: Completed
• Trial end date: 2007-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this project is to determine if a single dose of oral dexamethasone at the time of discharge from the emergency department (ED) [after successful treatment] prevents rebound headache.

Hypothesis: That single dose oral dexamethasone 8mg reduces the proportion of patients who suffer rebound headache after treatment for migraine in the ED.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Joseph Epstein Centre for Emergency Medicine Research
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Consenting adult patients [age >17 years] with physician-diagnosed migraine treated in the ED who are willing and able to be contacted between 48-72 hours after discharge for follow-up

Exclusion Criteria:

• Failure to consent

• Pregnancy

• Allergy to study medication

• Findings inconsistent with migraine

• Patients requiring hospital admission for further investigation and treatment

• Patients with active peptic ulcer disease

• Patients with Type 1 diabetes

• Patients taking corticosteroids for another condition within 7 days

• Active systemic fungal infection

• Patients previously enrolled in the study