Oral Dexamethasone for the Treatment of Cervical Radiculopathy

• Status: Terminated
• Trial end date: 2007-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether dexamethasone is effective in the treatment of pain and disability resulting from a compressed spinal nerve in the neck (cervical radiculopathy).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Manitoba
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Ages 18 - 60

• arm and neck pain consistent with cervical radiculopathy

• Neck Disability Index score of at least 15 (moderate)

• symptom onset between 2 weeks and 6 months prior to enrollment

Exclusion Criteria:

• Actively immunosuppressed state

• clinical red flags consistent with possible infection or malignancy

• acute febrile illness or infection requiring antibiotics

• upper motor neuron signs consistent with myelopathy

• previous orthopedic neck surgery in the area of that nerve root

• known hepatic dysfunction

• schizophrenia

• pregnancy/nursing mothers

• previous chronic corticosteroid use

• diabetes mellitus on treatment

• rapidly improving course

• osteoporosis

• hypersensitivity to product components

• systemic fungal infection

• recent administration of live vaccine

• active tuberculosis

• glaucoma

• peptic ulcer disease