Overview

Oral Medications for the Management of Acute Migraine Headache in the Emergency Department

Status:
Not yet recruiting

Trial end date:
2024-06-30

Target enrollment:
0

Participant gender:
All

Summary

The goal of this pilot randomized control trial is to assess the feasibility of our patient recruitment and data collection strategy ahead of a full scale RCT investigating the efficacy of oral v. parenteral medications in the management of acute migraine headaches in the emergency department. Patients will be randomly assigned to receive either (A) standard medical therapy for the treatment of acute migraine headache (metoclopramide and ketorolac IV) and oral placebo or (B) oral metoclopramide and ibuprofen with normal saline IV. Primary outcome measures are recruitment rate and improvement in pain score at 60 minutes from medication administration.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Health Sciences North Research Institute

Treatments:

Ibuprofen
Ketorolac
Metoclopramide

Criteria

Inclusion Criteria:

- Presentation to emergency department with headache

Exclusion Criteria:

- Vomiting or unable to tolerate PO at tie of med admin

- Focal neurologic symptoms

- Head trauma within 14d

- Pregnancy

- Concurrent use of blood thinners

- Hypersensitivity reaction to any of the study medications

- >14 HA days per month