Oral Melatonin in Critically Ill High-risk Patients

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Sleep disruptions are extremely common in high-risk critically ill patients. The investigators want to analyse oral melatonin potentialities as a sedative and a free-radicals scavenger for critically ill patients, and secondarily for preventing Delirium during their ICU stay and post-traumatic stress disorders after ICU discharge.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Milan
• Treatments: Melatonin

Criteria

Inclusion Criteria:

• High Treatment > 1 day

• Normal gastrointestinal function

Exclusion Criteria:

• Status asthmaticus

• Chronic renal failure under dialytic treatment

• Severe hepatopathy (Child-Pugh class = C)

• Comatous patients (GCS < 12)

• Head trauma, severe neurological diseases (ictus cerebri, SAH, ...)

• Intoxicated patients